Please use this identifier to cite or link to this item: http://223.31.159.10:8080/jspui/handle/123456789/1046
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dc.contributor.authorKumar, Sushil-
dc.contributor.authorKumari, Renu-
dc.contributor.authorPandey, Richa-
dc.date.accessioned2020-03-16T06:27:36Z-
dc.date.available2020-03-16T06:27:36Z-
dc.date.issued2020-
dc.identifier.citationProceedings of the National Academy of Sciences, India Section B: Biological Sciences, 90(1): 1-7en_US
dc.identifier.issn2250-1746-
dc.identifier.otherhttps://doi.org/10.1007/s40011-018-1031-8-
dc.identifier.urihttps://link.springer.com/article/10.1007/s40011-018-1031-8-
dc.identifier.urihttp://223.31.159.10:8080/jspui/handle/123456789/1046-
dc.descriptionAccepted date: 15 September 2018en_US
dc.description.abstractFruits of lychee tree (Litchi sinensis), extensively horticultured in India, China and many other countries, are delicious and possess many nutritious and medicinal properties. In India and other Asian countries, in lychee harvest season, outbreaks have been occurring of rapidly developing hypoglycaemia, encephalopathy, seizures and cerebral oedema in young children when they ingest lychee fruit arils in large numbers on empty stomach. It has been shown that the acute neurological illness is hypoglycaemic encephalopathy, caused by the actions of hypoglycin A (HGA) and methylenecyclopropylglycine (MCPG), the non-protein L-amino acids present in the edible arils of lychee fruits. Both HGA and MCPG phytotoxins are known to disrupt the pathways of β-fatty acid oxidation and gluconeogenesis in human body cells, result in accumulation of many undesirable metabolites of the blocked energy generating pathways, and altogether produced the often fatal hypoglycaemic illness. Here, the related work is summarized and commented upon and prospective genetical interventions in Litchi sinensis to eradicate the problem are outlined. Toxin-deficient lychee genotypes need to be developed by screening of germplasm accessions, and use of conventional and new site-directed mutagenesis technique of plant breeding. Lychee trees that produce super-toxin-rich (× 10 average toxin concentration) fruits are required to be identified and tagged to stop consumption of their fruits. New plantings must use toxin-deficient (low-toxin) lychee genotypes.en_US
dc.description.sponsorshipGrateful thanks are due to the Directors of NIPGR and IICT for facilities.en_US
dc.language.isoen_USen_US
dc.publisherThe National Academy of Sciences, Indiaen_US
dc.subjectAcute encephalopathyen_US
dc.subjectHypoglycaemiaen_US
dc.subjectHypoglycin Aen_US
dc.subjectHypoglycin Gen_US
dc.subjectLychee aril toxicityen_US
dc.subjectMethylenecyclopropylglycineen_US
dc.subjectSapindaceae fruitsen_US
dc.titleLychee-associated hypoglycaemic encephalopathy: A new disease of children described in Indiaen_US
dc.typeArticleen_US
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