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DC Field | Value | Language |
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dc.contributor.author | Sharma, Namisha | - |
dc.contributor.author | Muthamilarasan, Mehanathan | - |
dc.contributor.author | Prasad, Ashish | - |
dc.contributor.author | Prasad, Manoj | - |
dc.date.accessioned | 2020-07-29T09:37:26Z | - |
dc.date.available | 2020-07-29T09:37:26Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Genomics, 112(6): 4322-4331 | en_US |
dc.identifier.issn | 0888-7543 | - |
dc.identifier.other | https://www.sciencedirect.com/science/article/pii/S0888754320308958 | - |
dc.identifier.other | https://doi.org/10.1016/j.ygeno.2020.07.033 | - |
dc.identifier.uri | http://223.31.159.10:8080/jspui/handle/123456789/1082 | - |
dc.description | Accepted date: 20 July 2020 | en_US |
dc.description.abstract | COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is devastative to the humankind for which neither vaccines nor precise therapeutic molecules for treatment are identified. The search for new drugs and repurposing of existing drugs are being performed; however, at the same time, research on plants to identify novel therapeutic compounds or testing the existing ones is progressing at a slower phase. In this context, genomics and biotechnology offer various tools and strategies to manipulate plants for producing those complex biopharmaceutical products. This review enumerates the scope for research on plant-based molecules for their potential application in treating SARS-CoV-2 infection. Strategies to edit gene and genome, overexpression and silencing approaches, and molecular breeding for producing target biomolecules in the plant system are discussed in detail. Altogether, the present review provides a roadmap for expediting research on using plants as a novel source of active biomolecules having therapeutic applications. | en_US |
dc.description.sponsorship | Authors’ work in this area is supported by J.C. Bose National Fellowship Grant of Department of Science and Technology, Government of India (File No.: JCB/2018/000001). N.S. acknowledges the SERB Women Excellence Award from Science and Engineering Research Board, Govt. of India (File No. WEA/2020/000004). A.P. acknowledges the Council for Scientific and Industrial Research, Govt. of India for research fellowship. Authors are thankful to DBT-eLibrary Consortium (DeLCON) for providing access to e-resources. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier B.V. | en_US |
dc.subject | SARS-CoV-2 | en_US |
dc.subject | Coronavirus | en_US |
dc.subject | Genomics | en_US |
dc.subject | Genetic manipulation | en_US |
dc.subject | Therapeutics | en_US |
dc.subject | Plant-based drugs | en_US |
dc.subject | covid19 | en_US |
dc.title | Genomics approaches to synthesis plant-based biomolecules for therapeutic applications to combat SARS-CoV-2 | en_US |
dc.type | Article | en_US |
Appears in Collections: | Institutional Publications |
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Prasad M_2020_10.pdf Restricted Access | 1.55 MB | Adobe PDF | View/Open Request a copy |
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