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DC Field | Value | Language |
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dc.contributor.author | Maji, Sourobh | - |
dc.contributor.author | Waseem, Mohd | - |
dc.contributor.author | Sharma, Manish Kumar | - |
dc.contributor.author | Singh, Maninder | - |
dc.contributor.author | Singh, Anamika | - |
dc.contributor.author | Dwivedi, Nidhi | - |
dc.contributor.author | Thakur, Pallabi | - |
dc.contributor.author | Cooper, David G. | - |
dc.contributor.author | Bisht, Naveen C. | - |
dc.contributor.author | Fassler, Jan S. | - |
dc.contributor.author | Subbarao, Naidu | - |
dc.contributor.author | Khurana, Jitendra P. | - |
dc.contributor.author | Bhavesh, Neel Sarovar | - |
dc.contributor.author | Thakur, Jitendra K. | - |
dc.date.accessioned | 2024-07-10T07:00:52Z | - |
dc.date.available | 2024-07-10T07:00:52Z | - |
dc.date.issued | 2024 | - |
dc.identifier.citation | FEBS Journal, (In Press) | en_US |
dc.identifier.issn | 1742-464X | - |
dc.identifier.issn | 1742-4658 | - |
dc.identifier.other | https://doi.org/10.1111/febs.17225 | - |
dc.identifier.uri | https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.17225 | - |
dc.identifier.uri | http://223.31.159.10:8080/jspui/handle/123456789/1624 | - |
dc.description | Accepted date: 28 June 2024 | en_US |
dc.description.abstract | The protein-protein interaction (PPI) network of the Mediator complex is very tightly regulated and depends on different developmental and environmental cues. Here, we present an interactive platform for comparative analysis of the Mediator subunits from humans, baker's yeast Saccharomyces cerevisiae, and model plant Arabidopsis thaliana in a user-friendly web-interface database called MediatorWeb. MediatorWeb provides an interface to visualize and analyze the PPI network of Mediator subunits. The database facilitates downloading the untargeted and unweighted network of Mediator complex, its submodules, and individual Mediator subunits to better visualize the importance of individual Mediator subunits or their submodules. Further, MediatorWeb offers network visualization of the Mediator complex and interacting proteins that are functionally annotated. This feature provides clues to understand functions of Mediator subunits in different processes. In an additional tab, MediatorWeb provides quick access to secondary and tertiary structures, as well as residue-level contact information for Mediator subunits in each of the three model organisms. Another useful feature of MediatorWeb is detection of interologs based on orthologous analyses, which can provide clues to understand the functions of Mediator complex in less explored kingdoms. Thus, MediatorWeb and its features can help the user to understand the role of Mediator complex and its subunits in the transcription regulation of gene expression. | en_US |
dc.description.sponsorship | This study was supported by the grant BT/PR40146/ BTIS/137/4/2020 and BT/PR40169/BTIS/137/71/2023 from the Department of Biotechnology awarded to JKT. SM acknowledges fellowships from SERB, Government of India (NPDF fellow: PDF/2017/000811) and Department of Biotechnology, Government of India (MK Bhan Fellow: BT/HRD/MK-YRFP/50/27/2021). MW acknowledge fellowships from ICMR. AS acknowledges fellowship from Department of Biotechnology, Government of India (MK Bhan Fellow: BT/HRD/MK-YRFP/50/26/ 2021). PT acknowledges the fellowship from Council of Scientific and Industrial Research, India. The J.C. Bose National Fellowship awarded to Late Prof. Jitendra Paul Khurana by the Science and Engineering Research Board, Government of India, is also acknowledged. Support from all facilities of NIPGR and ICGEB are acknowledged. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | John Wiley & Sons | en_US |
dc.subject | Mediator complex | en_US |
dc.subject | Mediator subunit | en_US |
dc.subject | network | en_US |
dc.subject | protein–protein interaction | en_US |
dc.subject | transcription | en_US |
dc.title | MediatorWeb: a protein-protein interaction network database for the RNA polymerase II Mediator complex | en_US |
dc.type | Article | en_US |
Appears in Collections: | Institutional Publications |
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Thakur JK_2024_1.pdf Restricted Access | 3.99 MB | Adobe PDF | View/Open Request a copy |
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