Please use this identifier to cite or link to this item:
http://223.31.159.10:8080/jspui/handle/123456789/421
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | K, Muhammed Jamsheer | - |
dc.contributor.author | Laxmi, Ashverya | - |
dc.date.accessioned | 2015-12-17T06:40:45Z | - |
dc.date.available | 2015-12-17T06:40:45Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | PLoS One, 9(6): e99074 | en_US |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://172.16.0.77:8080/jspui/handle/123456789/421 | - |
dc.description | Accepted date: May 11, 2014 | en_US |
dc.description.abstract | Zinc fingers are a ubiquitous class of protein domain with considerable variation in structure and function. Zf-FCS is a highly diverged group of C2-C2 zinc finger which is present in animals, prokaryotes and viruses, but not in plants. In this study we identified that a plant specific domain of unknown function, DUF581 is a zf-FCS type zinc finger. Based on HMM-HMM comparison and signature motif similarity we named this domain as FCS-Like Zinc finger (FLZ) domain. A genome wide survey identified that FLZ domain containing genes are bryophytic in origin and this gene family is expanded in spermatophytes. Expression analysis of selected FLZ gene family members of A. thaliana identified an overlapping expression pattern suggesting a possible redundancy in their function. Unlike the zf-FCS domain, the FLZ domain found to be highly conserved in sequence and structure. Using a combination of bioinformatic and protein-protein interaction tools, we identified that FLZ domain is involved in protein-protein interaction. | en_US |
dc.description.sponsorship | This work was financially supported by the National Institute of Plant Genome Research (NIPGR) core grant and University Grants Commission, Government of India (research fellowship to MJK). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | PLOS | en_US |
dc.subject | DUF581 | en_US |
dc.subject | Zinc Finger | en_US |
dc.subject | Protein-Protein Interaction | en_US |
dc.title | DUF581 is plant specific FCS-like zinc finger involved in protein-protein interaction | en_US |
dc.type | Article | en_US |
dc.identifier.officialurl | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099074 | en_US |
dc.identifier.doi | 10.1371/journal.pone.0099074 | en_US |
Appears in Collections: | Institutional Publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Laxmi A_2014_2.pdf | 1.61 MB | Adobe PDF | View/Open |
Items in IR@NIPGR are protected by copyright, with all rights reserved, unless otherwise indicated.